Fig. 9. Neuronal survival was assessed at 7 days after combined controlled cortical impact (CCI) and hemorrhagic shock (HS) injury. Photomicrographs of representative hippocampal sections underlying the cortical contusion stained with hematoxylin and eosin. (A ) Mouse hippocampus after combined CCI plus HS injury and room air (RA) resuscitation (CCI+HS RA) and (B ) oxygen resuscitation (CCI+HS OXY). The loss of neurons in the CA1 region (white arrows ) does not appear to differ between groups on hematoxylin and eosin staining. There is gross degeneration of neuronal tissue in the CA3 region (black arrows ) of a mouse resuscitated with RA (A ) compared with oxygen (B ). Scatter plots of the number of surviving neurons (quantitated as linear density) in both (C ) CA1 and (D ) CA3 for CCI+HS RA and CCI+HS OXY groups with median represented by solid bar  (*P < 0.032, t  test).