Fig. 5. Xenon reduced the amplitudes but not the frequency of miniature excitatory postsynaptic currents (mEPSCs). mEPSCs were recorded in the presence of 1 μm tetrodotoxin, 50 μm AP5, 200 μm CGP35348, and 20 μm bicuculline methiodide at a holding potential of −70 mV. ( A ) Traces of mEPSCs recorded from one neuron in the basolateral amygdala in the absence and presence of 1.9 mm xenon. ( B ) Cumulative distributions of amplitudes and interevent intervals from one representative experiment. Xenon shifted the distribution of mEPSC amplitudes to smaller amplitudes but had no discernible effect on the distribution of interevent intervals. ( C ) Pooled data from five experiments. Error bars are SEMs . *P < 0.05. n.s. = not significant ( P > 0.05) .