Fig. 1. Concentration–response curves to levcromakalim (10−8to 3 × 10−6m) in the presence or in the absence of glibenclamide (10−6m), obtained in the rat aorta without endothelium contracted with phenylephrine (3 × 10−7m) or U46619 (3 × 10−8m). The data were expressed as means ± SD; n refers to the number of rats from which the aorta was taken, and they were expressed as percent of maximal relaxation induced by papaverine (3 × 10−4m). Difference between the control aorta and the aorta treated with glibenclamide (* P < 0.05) and that between the control aorta contracted with phenylephrine and the control contracted with U46619 (# P < 0.05) are statistically significant.
