Fig. 4. Response of cytoplasmic Ca2+concentration ([Ca2+]c) in sensory neurons to application of ionomycin in bath solution not containing Ca2+. ( A ) Sample traces from a control (C) neuron and another from the fifth lumbar (L5) dorsal root ganglion after spinal nerve ligation (SNL). ( B ) Application of ionomycin produces transients with reduced amplitude in L5 neurons, but increased amplitude in L4 neurons (one-way ANOVA with Bonferroni post hoc testing). Numbers in bars indicate n for number of neurons, brackets above bars connect groups that are significantly different ( P < 0.05), and error bars show SD.