Fig. 8. Adrenocorticotropic hormone^1–24–stimulated serum corticosterone concentrations in rats 30 min after administration of vehicle, etomidate, or methoxycarbonyl-etomidate (MOC-etomidate). Drugs were given at doses equal to twice their respective ED⁵⁰s for loss of righting reflex. Four rats were studied in each group. Average serum corticosterone concentrations (± SD) were 740 ± 125 ng/ml, 320 ± 97 ng/ml, and 750 ± 58 ng/ml after administration of vehicle, etomidate, and methoxycarbonyl-etomidate, respectively. *  P < 0.05. N.S. = no significant difference.