Fig. 6. Effects of various inhibitors on enhanced contractile response to norepinephrine (NE) by sevoflurane (A ) or isoflurane (B ) in endothelium-intact strips from control (i.e ., nondiabetic) rats. The inhibitors tested in these experiments were adrenomedulin22–52(AM22–52, 0.3–1 μm), calcitonin gene-related peptide8–37(CGRP8–37, 0.3–1 μm), 18β-glycyrrhetinic acid (18β-GA, 3–10 μm), losartan (1–3 μm), ketanserin (0.03–0.1 μm), BQ-123 (1 μm), BQ-788 (1 μm), N G-nitro l-arginine (LNNA, 100 μm), indomethacin (10 μm), Ba2+(30 μm), and ouabain (1 mm), n = 5. *P < 0.05 versus control (100%). NS = not significantly different (P > 0.05).