Fig. 2. The return to consciousness effect found with antibody infusion during desflurane anesthesia is site-specific. (  A ) The central medial thalamus target is shown on rat atlas figure (  arrowed ), located to the left. Expanded insets show infusion sites (  black dots ) for the infusions that had no-effect  versus those that restored consciousness. (  B ) The return to consciousness response is significantly associated with infusions that hit the central medial thalamus (  gray highlighted area in,  A )  versus those that missed. Reprinted with permission from Alkire MT  et al. Anesthesiology 2009; 110:766–75.