Fig. 7. Adrenocorticotropic hormone1–24-stimulated serum corticosterone concentrations in rats 15 min after administration of vehicle, 2 mg/kg of etomidate, or 14 mg/kg of carboetomidate. Hypnotics were given at doses equal to twice their respective ED50s for loss of righting reflex. Four rats were studied in each group. Average serum corticosterone concentrations (±SD) were 390 ± 50 ng/ml, 120 ± 80 ng/ml, and 330 ± 70 ng/ml after administration of dimethyl sulfoxide vehicle (control), etomidate, and carboetomidate, respectively. *P < 0.05. N.S. = no significant difference.
