Fig. 6. Time course of the effects of intrathecal injection of dynorphin A (1–17) (30 pmol) on blood oxygenation level-dependent (BOLD) signal intensity in the cingulate cortex (CG), somatosensory cortex (S1), insula cortex (IC), medial thalamic region (mTH), and lateral thalamic region (lTH) in mice. Representative activation maps (overlaid on anatomy) correspond to composite images at 0 or 2 h (A-i : CG), 0 or 1 h (B-i : S1, C-i : IC, D-i ; mTH), and 0 or 0.5 h (E-i : lTH) after the intrathecal injection of dynorphin A (1–17) in mice. The intrathecal injection of dynorphin A (1–17) produced a significant increase in BOLD signal compared with basal intensity (A-ii : CG; B-ii : S1; C-ii : IC; D-ii  mTH; E-ii : lTH). Each point indicates the mean ± SEM for five mice. CFA = complete Freund's adjuvant.

Fig. 6. Time course of the effects of intrathecal injection of dynorphin A (1–17) (30 pmol) on blood oxygenation level-dependent (BOLD) signal intensity in the cingulate cortex (CG), somatosensory cortex (S1), insula cortex (IC), medial thalamic region (mTH), and lateral thalamic region (lTH) in mice. Representative activation maps (overlaid on anatomy) correspond to composite images at 0 or 2 h (A-i : CG), 0 or 1 h (B-i : S1, C-i : IC, D-i ; mTH), and 0 or 0.5 h (E-i : lTH) after the intrathecal injection of dynorphin A (1–17) in mice. The intrathecal injection of dynorphin A (1–17) produced a significant increase in BOLD signal compared with basal intensity (A-ii : CG; B-ii : S1; C-ii : IC; D-ii  mTH; E-ii : lTH). Each point indicates the mean ± SEM for five mice. CFA = complete Freund's adjuvant.

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