Fig. 1. The intrathecal injection of PSD-95/SAP90 antisense oligodeoxynucleotide (AS, 50 μg; n = 8) significantly inhibited PSD-95/SAP90 expression in both the ventral horn and the dorsal horn of the lumbar spinal cord. Neither missense (MS, 50 μg; n = 8) nor saline (SA; n = 6) injection had an effect. Tubulin served as a loading control. (A , C ) Whole lumbar spinal cord; (B , D ) the ventral horn and dorsal horn. No injection was given for sham (SH) rats (n = 6). The data shown are representative of three independent experiments (A , B ) and the results after statistical analysis (C , D ). *P < 0.05 versus SA group. PSD = postsynaptic density protein.