Fig. 4. Effect of PSD-95/SAP90 knockdown on halothane minimum alveolar concentration (MAC) in wild-type (WT) and PSD-93/Chapsyn-110 knockout (KO) mice. The intrathecal injection of PSD-95/SAP90 antisense oligodeoxynucleotide (AS) reduced halothane MAC in both WT and PSD-93/Chapsyn-110 KO mice at a similar level. AS, n = 8 for each dose; missense oligodeoxynucleotide (MS), n = 8. *P < 0.05 versus  saline group (n = 6) in WT mice and # P < 0.05 versus  saline group (n = 6) in PSD-93/Chapsyn-110 KO mice. PSD = postsynaptic density protein.