Fig. 1. Significant reductions in motor response amplitude. Traces on the left show representative transcranial electric motor-evoked potentials (tceMEPs) recorded from left first dorsal interosseous (FDI) and tibialis anterior (TA) muscles from a patient who had significant reductions in motor response amplitude from baseline after loading dose infusion of dexmedetomidine (Dex) (target plasma level = 0.8 ng/ml). Responses gradually recovered during a 2-h period after discontinuation of Dex infusion. Traces on the right show representative cortical somatosensory-evoked potentials (SSEPs) to stimulation of the left ulnar nerve during the same time periods. There were no significant changes in SSEP amplitude. Fpz-Cz = designation for specific locations on the scalp.