Fig. 3. Context-sensitive half-times as a function of infusion duration for each of the pharmacokinetic models simulated. Solid  and dashed line  patterns are used only to permit overlapping lines to be distinguished. Reprinted with permission from Hughes MA, Glass PSA, Jacobs JR: Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology 1992; 76:334–41.