Fig. 6.  Specific inhibition of RhoA decreases perivascular edema caused by the airspace instillation of Pseudomonas aeruginosa  in mice. (A ) Low-power photomicrographs of lung sections stained with hematoxylin and eosin. Control and CGX0287-treated C57BL/6 mice show normal lung physiology (A  and B ). Mice instilled with P. aeruginosa  and CGX0287 vehicle show microscopic evidence of perivascular edema (C ). Pretreatment with a specific RhoA inhibitor (CGX0287, 50 mg/kg intraperitoneally) decreases perivascular edema induced by airspace P. aeruginosa  (D ). (B  and C ) Histologic analysis of the perivascular edema thickness and of the perivascular edema/vessel wall ratio measured with a micrometer on 20 vessels for each lung. Results are shown as mean ± SD (n = 6 mice in each experimental group); *P ≤ 0.05 from controls; **P ≤ 0.05 from mice instilled with P. aeruginosa  and CGX0287 vehicle. PAK =Pseudomonas aeruginosa  strain K.