Fig. 6.  Effect of inositol 1,4,5-triphosphate receptor-blocker xestospongin C (XeC) on 4-chloro-m-cresol-induced adenosine formation by porcine lymphocytes cells. Cells (1-2 × 10⁶) from normal swine (n = 5) were suspended in Ca²⁺/Mg²⁺-free Hank's balanced salt solution plus adenosine deaminase inhibitor ((erythro-9(2-hydroxy-3-nonyl) adenine, 1 mm). Samples were treated for 10 min at 37°C with different XeC concentrations as indicated in the figure. This protocol phase was followed by treatment with 2 mm 4CmC and incubation at 37°C for additional 30 min. *XeC (10 μM) significantly (P = 0.002) reduced 4CmC (2 mm)-induced adenosine formation.