Fig. 3.  QX-314 effects on transient receptor potential vanilloid subfamily member 4 (TRPV4) channels expressed in Xenopus laevis  oocytes. In contrast to its activation of TRPV1 channels (fig. 2), QX-314 (60 mM; n = 7) elicited no responses in TRPV4 channels (the closest TRPV1 homolog), compared with control currents elicited by 500 nM GSK1016790A (see Materials and Methods and Drugs and Chemicals); for details, see Results. GSK101 = GSK1016790A.