Fig. 3.  Histopathologic features (A ) and time course (B ) of macrophage (iba1 or CD11b-positive) infiltration in the sciatic nerves of wild-type C57BL/6C, nonobese diabetic (NOD/Lt), and nonobese diabetic–severe combined immune deficiency (NOD-SCID) mice after partial sciatic nerve ligation (PSNL) versus  sham surgery. Macrophages were detected at the site of injury in C57BL/6C mice (intact immune function) at later stages (days 7–14), with macrophage numbers peaking at day 7 postinjury. Compared with intact immune function mice, immunocompromised mice (NOD/Lt and NOD-SCID) had significantly less macrophage infiltration in the injured nerve. This difference was more prominent among NOD-SCID mice. Data are presented as mean ± SD (n = 6). *P < 0.05 versus  C57BL/6C, #P < 0.05 versus  NOD/Lt; two-way repeated-measures ANOVA with Bonferroni adjustment.