Fig. 8. Expressions of peripheral opioid peptide messenger RNA were decreased in immunocompromised mice after partial sciatic nerve ligation (PSNL). (A–C ) Baseline expression values of enkephalins, dynorphin, and β-endorphin were not different within groups. Expression levels of these opioid peptides were much lower in immunocompromised nonobese diabetic (NOD/Lt), and nonobese diabetic–severe combined immune deficiency (NOD-SCID) mice than in wild-type C57BL/6C mice. Results are expressed as mean ± SD. For each data set, n = 4. *P < 0.05 versus C57BL/6C, #P < 0.05 versus NOD/Lt; two-way repeated-measures ANOVA with Bonferroni adjustment. (D–F ) expression values of enkephalins, dynorphin, and β-endorphin were subsequently increased after PSNL in C57BL/6C and NOD/Lt mice. *P < 0.05 versus control (day 0), #P < versus day 1; one-way ANOVA with Dunnett test.