Fig. 4. Two types of anesthetic responses in brain networks. The subjects were classified into two types of groups based on the alterations of connection strength. (A and B ) Individual traces of e top(top tracing) and e str(bottom tracing) for the type 1 (n = 8) and type 2 (n = 12) responses. (C ) The mean values of the type 1 group in which the e strshowed a pattern of “slow decay and sudden return” at loss of consciousness (LOC) and recovery of consciousness (ROC). (D ) By contrast, in the average trace of the type 2 group the e strshowed a pattern of “sudden decay and slow return” at LOC and ROC. Network topology e topdemonstrated a consistent response in all subjects.