Fig. 6. Effects of propofol on single-channel function in wild type and mutated glycine receptor (GlyRs) and γ-aminobutyric acid type A receptor (GABA^AR). (A ) Single-channel activity recorded in wild type and F380A GlyRs (calibration bar; 5 pA, 10 ms). (B ) Percentage of the open probability (nPo) potentiation by propofol in the wild type and F380A GlyRs. (C ) Main conductance of the wild type and F380A GlyRs. (D ) Single-channel activity recorded in the wild type and F385A GABA^AR (calibration bar; 2 pA, 10 ms). (E ) Percentage of nPo potentiation in the wild type and F385A GABA^ARs by propofol. (F ) Main conductance of the wild type and F385A GABA^Areceptor. The bars represent the mean ± SEM. *** Significance of P < 0.001.