Fig. 3. Mean serum interleukin-1 receptor antagonist (IL-1Ra) concentrations at baseline and 24 h postoperatively for three genotype classes. Bars represent 1 SE. Carriers of *2 were statistically different from *1 and *3 at baseline (*1 vs. *2 : P = 0.003; *2 vs. *3 : P = 0.008) and at 24 h (*1 vs. *2 : P = 0.005; *2 vs. *3 : P = 0.001). After adjusting for age, sex, ethnicity, body mass index, smoking, and surgical approach, differences at 24 h remained statistically significant.