Fig. 2. In WT (n = 6), LTC4S−/−(n = 6), and CysLT1−/−mice (n = 7), the circulating leukocyte concentrations were markedly reduced after lipopolysaccharide challenge compared with WT (n = 6), LTC4S−/−(n = 7), and CysLT1−/−(n = 6) mice after saline challenge (A ). Lung tissue myeloperoxidase activity was greater in lipopolysaccharide-treated WT (n = 5), LTC4S−/−(n = 7), and CysLT1−/−(n = 7) mice than in saline-treated WT (n = 6), LTC4S−/−(n = 6), and CysLT1−/−(n = 6) mice. Blood and tissue samples were taken 18 h after lipopolysaccharide challenge (B ). *P < 0.05 versus saline-challenged mice of the respective genotype. CysLT1−/−= mice congenitally deficient in the cysteinyl leukotriene receptor 1; LPS = lipopolysaccharide; LTC4S−/−= mice congenitally deficient in leukotriene C4synthase; MPO = myeloperoxidase; WBC = leukocyte count; WT = wild-type. All data mean ± SD.