Fig. 2. Mouse mortality during polymicrobial sepsis. Age-matched WT, MyD88−/−, and Trif−/−mice were subjected to CLP or sham procedures and the mortality of the septic mice were assessed daily for up to 14 days. CLP = cecum ligation and puncture; MyD88 = myeloid differentiation factor 88; Trif = TIR-domain-containing adaptor protein inducing interferon-β mediated transcription-factor; WT = wild-type. The number of animals in each group: WT-Sham = 5, WT-CLP = 5, MyD88−/−-Sham = 5, MyD88−/−-CLP = 6, Trif−/−-Sham = 5, Trif−/−-CLP = 6. *P < 0.05 versus WT-CLP.