Fig. 1.  Experimental design relative to the propofol infusion and data collection scheme. The electroencephalogram and clinical signs were recorded and analyzed at the moment of extubation (R^ext), although no blood sampling was performed. Arrows with R = moments of recording of electroencephalogram, clinical evaluation of anesthetic depth and arterial blood samples; R⁰= at baseline; R¹, R², R³= during each infusion 20, 25, and 30 min after the beginning of the respective infusion rate; R^rec= in the totally recovered animal.