Fig. 6. Effect of pretreatment with olanzapine on the morphine-induced (A ) inhibition of gastrointestinal transit and the effect of olanzapine itself (B ). Each column represents the mean ± SEM of six mice. Ink was administered orally 20 min after the injection of morphine (0.7 mg/kg, subcutaneous injection) or saline, respectively. Groups of mice were pretreated with olanzapine (0.03–1 mg/kg, subcutaneous injection) at 30 min before the administration of morphine. Gastrointestinal transit was evaluated at 20 min after the oral administration of ink. Statistical analyses were performed with one-way ANOVA followed by the Bonferroni multiple comparisons test: F(5,35) = 15.99, P < 0.0001 (A ); F(4,29) = 5.778, P = 0.0020 (B ). *P < 0.05, ***P < 0.001 versus  vehicle-saline.

Fig. 6. Effect of pretreatment with olanzapine on the morphine-induced (A ) inhibition of gastrointestinal transit and the effect of olanzapine itself (B ). Each column represents the mean ± SEM of six mice. Ink was administered orally 20 min after the injection of morphine (0.7 mg/kg, subcutaneous injection) or saline, respectively. Groups of mice were pretreated with olanzapine (0.03–1 mg/kg, subcutaneous injection) at 30 min before the administration of morphine. Gastrointestinal transit was evaluated at 20 min after the oral administration of ink. Statistical analyses were performed with one-way ANOVA followed by the Bonferroni multiple comparisons test: F(5,35) = 15.99, P < 0.0001 (A ); F(4,29) = 5.778, P = 0.0020 (B ). *P < 0.05, ***P < 0.001 versus  vehicle-saline.

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