![Fig. 3. Concentration-response curve of propofol-mediated inhibition of sevoflurane protection. (A ) Left ventricular work (LVW). (B ) Diastolic [Ca2+]i. (C ) Representative [Ca2+]itraces of 1-s duration. INDO, Ca2+indicator indo-1 AM; IR, ischemia–reperfusion alone; SEVO+IR, periischemic sevoflurane treatment (2 vol.-%); SEVO/P0.1+IR, periischemic sevoflurane (2 vol.-%) plus propofol (0.1 μM) treatment; SEVO/P1+IR, periischemic sevoflurane (2 vol.-%) plus propofol (1 μM) treatment; SEVO/P10+IR, periischemic sevoflurane (2 vol.-%) plus propofol (10 μM) treatment; SEVO/P100+IR, periischemic sevoflurane (2 vol.-%) plus propofol (100 μM) treatment. *P < 0.05 compared with IR. Data are mean ± SD (A ) and median (25th, 75th percentile) (B ).](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/116/3/10.1097_aln.0b013e318247225a/2/24ff3.png?Expires=1717064285&Signature=1ujOVK9k7DjZ1omLHiaHeaThF2mJ0I-RSvoYVuKxrwAP74Uh1WUC80CnwQviMYQOv1JKRf0D5u4jA5BDFH~fXvBq-VgszSPDgeZkkOPjwolqlldCyLySUNEqay9bMc6Sr-DrXAZPEwoGG0fkHpr6tQ93jd2~aMTG6py4sMMIQKZcWAQWoyH4cHFYuQXxXti-7usB-5yoDentSrtI4e1y4sihsKQliA2WYW4-6mah3WvilmKBGFE56WHzkJcBHBXERYvfqVhENc209USEtz-1ERughho5xMQtqn1afKmmnWfzoD52SGZekfILR-eWwa5Lo3tOZ-KyjG6D2yLmFnFTNg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 3. Concentration-response curve of propofol-mediated inhibition of sevoflurane protection. (A ) Left ventricular work (LVW). (B ) Diastolic [Ca2+]i. (C ) Representative [Ca2+]itraces of 1-s duration. INDO, Ca2+indicator indo-1 AM; IR, ischemia–reperfusion alone; SEVO+IR, periischemic sevoflurane treatment (2 vol.-%); SEVO/P0.1+IR, periischemic sevoflurane (2 vol.-%) plus propofol (0.1 μM) treatment; SEVO/P1+IR, periischemic sevoflurane (2 vol.-%) plus propofol (1 μM) treatment; SEVO/P10+IR, periischemic sevoflurane (2 vol.-%) plus propofol (10 μM) treatment; SEVO/P100+IR, periischemic sevoflurane (2 vol.-%) plus propofol (100 μM) treatment. *P < 0.05 compared with IR. Data are mean ± SD (A ) and median (25th, 75th percentile) (B ).
