Fig. 4. Incidence of intraoperative massive transfusion (≥10 units of packed red blood cells), unplanned reexploration surgery within 48 h following initial surgery, and composite thrombotic/thromboembolic adverse events (venous thrombosis, pulmonary embolism, other arterial embolism, stroke, and coronary bypass graft occlusion) in patients undergoing cardiovascular surgery before (2004) and after (2009) implementation of a point-of-care-supported coagulation management algorithm.