Fig. 5. Phenotypes of potential acy-1  signaling pathway mutants. Isoflurane EC⁵⁰values for various genes hypothesized to lie in the acy-1  signaling pathway (*P < 0.01 vs.  wild type) (A ). js127  increases sensitivity of crh-1  (n3315 ) to 0.35 mM aldicarb (P < 0.01) (B ). Aldicarb resistance (0.35 mM) of unc-10(md1117 ) is not significantly suppressed by js127  (C ). Aldicarb resistance (0.35 mM) of snb-1(md247 ) is not significantly suppressed by js127  (D ). Aldicarb resistance (0.35 mM) of unc-13(e376 ) is not significantly suppressed by js127  (E ). js127  mutation enhances the locomotion of several lethargic mutants but not unc-13  (s69 ) (*P < 0.01 vs.  lethargic single mutant) (F ).