Fig. 2. Sepsis-induced loss of immune effector cells. Sepsis causes a profound depletion of cells of the innate and adaptive immune system. As shown in the color photomicrographs, sepsis induces a major loss of B cells, CD4+ T cells, and follicular dendritic cells in spleens from a patient with sepsis compared with spleens removed from critically ill nonseptic patients. Magnification: ×200. (Modified with permission from Nat Rev Immunol 2006; 6:813–22. Used with permission. Copyright © Nature Publishing Group 2006.)