Fig. 6. Spared nerve injury-induced mechanical allodynia in protein kinase C knockout mice. (A ) Spared nerve injury-induced allodynia is enhanced in protein kinase Cα knockout mice (*P < 0.05, representing group main effects), attenuated in protein kinase Cγ knockout mice (***P < 0.01) (C ), and unchanged in PKCβ and PKCδ knockout mice (B and D ) compared with respective wild-type littermate control mice. Details of the spared nerve injury procedure are provided in Materials and Methods. For all experiments, the experimenter was blind to genotype of the animals. KO = knockout; WT = wild type.