Fig. 2. Anesthetized rats (n = 6), breathing spontaneously, subjected to sustained ventilatory depression through continuous remifentanil infusion. The start of the remifentanil infusion is marked by an arrow ; remifentanil was given continuously throughout experiments. Repinotan increased spontaneous minute ventilation (MV) in a dose-dependent manner from −56 [−67 to −52]% (remifentanil level) to a maximum of −4 [−8 to 35]% of the pretreatment level with the 100-μg/kg dose. 8-OH-DPAT ([+]-8-Hydroxy-2-(di-n-propylamino)-tetralin) (n = 6) raised MV to 32 [−6 to 36]% at 10 μg/kg. MV remained depressed in controls with NaCl (0.9%) (n = 6). MV is shown as median percent change from the pretreatment level (%change) with interquartile range [IQR]. MV %change = 100 × (MVtreatment/MVpretreatment) − 100. *P < 0.05; **P < 0.01; Friedman's ANOVA and Dunn's multiple comparison test, compared with remifentanil concentrations.

Fig. 2. Anesthetized rats (n = 6), breathing spontaneously, subjected to sustained ventilatory depression through continuous remifentanil infusion. The start of the remifentanil infusion is marked by an arrow ; remifentanil was given continuously throughout experiments. Repinotan increased spontaneous minute ventilation (MV) in a dose-dependent manner from −56 [−67 to −52]% (remifentanil level) to a maximum of −4 [−8 to 35]% of the pretreatment level with the 100-μg/kg dose. 8-OH-DPAT ([+]-8-Hydroxy-2-(di-n-propylamino)-tetralin) (n = 6) raised MV to 32 [−6 to 36]% at 10 μg/kg. MV remained depressed in controls with NaCl (0.9%) (n = 6). MV is shown as median percent change from the pretreatment level (%change) with interquartile range [IQR]. MV %change = 100 × (MVtreatment/MVpretreatment) − 100. *P < 0.05; **P < 0.01; Friedman's ANOVA and Dunn's multiple comparison test, compared with remifentanil concentrations.

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