Fig. 2. Effects of regional or whole-body hypothermic treatment on the discharge activity of the injured median nerve. A low frequency of spikes was observed in sham-operated rats treated with regional normothermia (A  a). In contrast, high rates of nerve discharge were seen in chronic constriction injury (CCI) rats pretreated with regional normothermia (A  b). In CCI rats pretreated with mild (A  c) or deep regional hypothermia (A  d), the discharge rate was decreased. (B ) A significant decrease in the rate of nerve discharge was noted after application of regional hypothermia (P < 0.05, by two-way ANOVA). In preinjury, 5 h, 1 day, and 3 days postinjury groups, the discharge rates were significantly decreased in CCI rats treated with mild or deep regional hypothermia compared with those treated with regional normothermia (*P < 0.05, by Tukey test). On postinjury day 5, deep, but not mild, regional hypothermia significantly decreased the rate of nerve discharge compared with regional normothermia (*P < 0.05, by Tukey test). Further, the discharge rate was significantly lower in CCI rats that received deep regional hypothermia than mild regional hypothermia (#P < 0.05, by Tukey test). (C ) A significant decrease in the rate of nerve discharge was achieved after applying whole-body hypothermia (P < 0.05, by two-way ANOVA). The discharge rate was significantly decreased in CCI rats treated with mild or deep whole-body hypothermia compared with whole-body normothermia in preinjury, 5 h, 1 day, and 3 days postinjury groups (*P < 0.05, by Tukey test). Deep whole-body hypothermia, but not mild whole-body hypothermia, significantly decreased the rate of discharge compared with whole-body normothermia on postinjury day 5 (*P < 0.05, by Tukey test). In addition, the discharge activity was significantly lower in CCI rats that received deep whole-body hypothermia than in those that received mild whole-body hypothermia (#P < 0.05, by Tukey test). Regional and whole-body hypothermia, either mild or deep, had similar effects on the nerve discharge rate (P > 0.05, by two-way ANOVA). Error bars  represent mean ± SD; n = 6 or 7 rats per treatment.

Fig. 2. Effects of regional or whole-body hypothermic treatment on the discharge activity of the injured median nerve. A low frequency of spikes was observed in sham-operated rats treated with regional normothermia (A  a). In contrast, high rates of nerve discharge were seen in chronic constriction injury (CCI) rats pretreated with regional normothermia (A  b). In CCI rats pretreated with mild (A  c) or deep regional hypothermia (A  d), the discharge rate was decreased. (B ) A significant decrease in the rate of nerve discharge was noted after application of regional hypothermia (P < 0.05, by two-way ANOVA). In preinjury, 5 h, 1 day, and 3 days postinjury groups, the discharge rates were significantly decreased in CCI rats treated with mild or deep regional hypothermia compared with those treated with regional normothermia (*P < 0.05, by Tukey test). On postinjury day 5, deep, but not mild, regional hypothermia significantly decreased the rate of nerve discharge compared with regional normothermia (*P < 0.05, by Tukey test). Further, the discharge rate was significantly lower in CCI rats that received deep regional hypothermia than mild regional hypothermia (#P < 0.05, by Tukey test). (C ) A significant decrease in the rate of nerve discharge was achieved after applying whole-body hypothermia (P < 0.05, by two-way ANOVA). The discharge rate was significantly decreased in CCI rats treated with mild or deep whole-body hypothermia compared with whole-body normothermia in preinjury, 5 h, 1 day, and 3 days postinjury groups (*P < 0.05, by Tukey test). Deep whole-body hypothermia, but not mild whole-body hypothermia, significantly decreased the rate of discharge compared with whole-body normothermia on postinjury day 5 (*P < 0.05, by Tukey test). In addition, the discharge activity was significantly lower in CCI rats that received deep whole-body hypothermia than in those that received mild whole-body hypothermia (#P < 0.05, by Tukey test). Regional and whole-body hypothermia, either mild or deep, had similar effects on the nerve discharge rate (P > 0.05, by two-way ANOVA). Error bars  represent mean ± SD; n = 6 or 7 rats per treatment.

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