Fig. 4. Results from the simulations showing the median (red lines ) and 90% simulation interval (black lines ) for area under the plasma concentration-time curve (AUC) (A ), valdecoxib half-life (t½) (B ), valdecoxib maximum plasma concentration (C^max) (C ), and estimated valdecoxib duration of action (D ), as the time (h) for free valdecoxib concentration above the in vitro  50% inhibitory concentration (IC⁵⁰). Solid lines  represent smoothed data averaged from 2000 simulated children from both sexes in yearly age increments. Plots are limited to the age range for the children in the study (1.1–12.7 yr). The horizontal dashed line  in A  shows a value of 6640 μg · h/l being the pooled average AUC for 40 mg parecoxib in adults and a pink shaded area  from 3775–9498 μg · h/l representing the pooled 90% prediction interval AUC for 40 mg parecoxib in adults. The horizontal dotted line  in D  shows time at 12 h after dose.