Fig. 5. Cerebrospinal fluid concentrations of methoxycarbonyl etomidate before, during, and after 30-min continuous infusions of methoxycarbonyl etomidate or methoxycarbonyl etomidate's carboxylic acid metabolite (MOC-ECA). The total infused dose of methoxycarbonyl etomidate or MOC-ECA was 540 mg/kg, which was delivered using the infusion protocol defined from closed-loop infusion experiments. *P < 0.05 versus  time 0; one-way analysis of variance followed by a Dunnett posttest. The dashed line  indicates our lower limit of quantitation (LLOQ). All data represent the mean ± SD from three rats.