Fig. 2. Dose response of intralipid and cyclosporine-A in ex vivo  ischemia-reperfusion mouse model. (A ) Rate pressure product as a function of time in 0.5%, 1%, and 2% intralipid (n = 7). (B ) The area of necrosis as the percentage of total ventricular area in 0.5%, 1%, and 2% intralipid group. (C ) Rate pressure product as a function of time in 0.2 μM, 0.8 μM, and 1.5 μM cyclosporine-A (n = 5). (D ) The area of necrosis as the percentage of total ventricular area in control group, 0.5%, 1%, and 2% intralipid group. *P = 0.022, 2% intralipid versus  0.5% intralipid; **P = 0.004, 1% intralipid versus  0.5% intralipid; &&P = 0.008, 0.8 μM cyclosporine-A versus  0.2 μM cyclosporine-A; ^^P = 0.009, 1.5 μM cyclosporine-A versus  0.2 μM cyclosporine-A. CsA = cyclosporine-A; ILP = intralipid; RPP = rate pressure product.

Fig. 2. Dose response of intralipid and cyclosporine-A in ex vivo  ischemia-reperfusion mouse model. (A ) Rate pressure product as a function of time in 0.5%, 1%, and 2% intralipid (n = 7). (B ) The area of necrosis as the percentage of total ventricular area in 0.5%, 1%, and 2% intralipid group. (C ) Rate pressure product as a function of time in 0.2 μM, 0.8 μM, and 1.5 μM cyclosporine-A (n = 5). (D ) The area of necrosis as the percentage of total ventricular area in control group, 0.5%, 1%, and 2% intralipid group. *P = 0.022, 2% intralipid versus  0.5% intralipid; **P = 0.004, 1% intralipid versus  0.5% intralipid; &&P = 0.008, 0.8 μM cyclosporine-A versus  0.2 μM cyclosporine-A; ^^P = 0.009, 1.5 μM cyclosporine-A versus  0.2 μM cyclosporine-A. CsA = cyclosporine-A; ILP = intralipid; RPP = rate pressure product.

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