Fig. 6. Effect of chronic neuropathic pain and chronic mild stress on (A ) weight, (B ) food intake, and (C ) physical state over time. Experimental groups: Sham-control (sham-operated without CMS, n = 10), Sham-CMS (sham-operated subjected to CMS, n = 11), CCI-control (animals with neuropathic pain not subjected CMS, n = 12), and CCI-CMS (animals with neuropathic pain subjected to CMS, n = 12). Each symbol represents the mean + SEM. Statistical analysis: *P less than 0.05, ***P less than 0.001 versus sham-control; #P less than 0.05, ###P less than 0.001 versus CCI-control. CCI = chronic constriction injury; CMS = chronic mild stress; E1 and E2 = first and second week of the experimentation phase; H1, H2, and H3 =first, second and third week of the habituation.