Fig. 4. Delay in treatment with TT-301 after traumatic brain injury is still associated with improved functional outcome. Even when treatment was initiated 6 h instead of 30 min after injury with TBI, administration of TT-301 was associated with functional improvement, as demonstrated by improved Rotorod performance (A ) over the first 7 days after injury and shorter Morris water maze latencies (B ) 4 weeks after injury as compared with vehicle-treated mice, despite similar swimming speeds. *P < 0.05 as assessed by ANOVA. Mortality between the groups was not significant [TT-301 (1 mg/kg) groups vs.  Vehicle: 0% v. 8.3% (1 of 12)].