Fig. 1. Hemostatic therapy algorithms. (A ) Intraoperative conventional algorithm. (B ) Postoperative conventional algorithm. (C ) Intraoperative POC algorithm. (D ) Postoperative POC algorithm. ACT = activated clotting time; ADP = ADPtest®; aPPT = activated partial prothrombin time; ASPI = ASPItest®; AU = aggregation unit; A10 = amplitude of clot firmness 10 min after clotting time; Caⁱ= ionized calcium; CPB = cardiopulmonary bypass; CT = clotting time; EX = EXTEM®; FFP = fresh frozen plasma; FIB = FIBTEM®; F XIII = factor XIII concentrate; HEP = HEPTEM®; ICU = intensive care unit; IN = INTEM®; INR = international normalized ratio; MCF = maximum clot firmness; PC = pooled platelet concentrate; PCC = prothrombin complex concentrate; rFVIIa = activated recombinant factor VII; Tc = core temperature; TRAP = TRAPtest®. Manufacturer of ROTEM® and Multiplate® were Tem International GmbH, Munich, Germany, and Verum Diagnostica GmbH, Munich, Germany, respectively.