Fig. 6. Assessment of secretory phospholipase A2 inhibitor effects on phospholipase A2 activating protein (PLAA)- or incision-induced mechanical and thermal allodynia. Blocking secretory phospholipase A2 activity reversed PLAA- (A ) or incision-induced (B ) mechanical allodynia, but did not change incision-induced thermal hyperalgesia (C ). Values are displayed as the mean ± SEM, n = 6, **P < 0.01, ***P < 0.001 versus  control group; #P < 0.05, ##P < 0.01, or ###P < 0.001 versus  only PLAA-treated (10 μg) group. HK064 = secretory phospholipase A2 inhibitor; PLAA = phospholipase A2 activating protein.

Fig. 6. Assessment of secretory phospholipase A2 inhibitor effects on phospholipase A2 activating protein (PLAA)- or incision-induced mechanical and thermal allodynia. Blocking secretory phospholipase A2 activity reversed PLAA- (A ) or incision-induced (B ) mechanical allodynia, but did not change incision-induced thermal hyperalgesia (C ). Values are displayed as the mean ± SEM, n = 6, **P < 0.01, ***P < 0.001 versus  control group; #P < 0.05, ##P < 0.01, or ###P < 0.001 versus  only PLAA-treated (10 μg) group. HK064 = secretory phospholipase A2 inhibitor; PLAA = phospholipase A2 activating protein.

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