Fig. 4. Transcriptional regulation of substance P, calcitonin gene-related peptide (CGRP), and μ-opioid receptor (MOR) in the dorsal root ganglia (DRG) induced by peritoneal carcinomatosis. Expression of substance P (A ), CGRP (B ), and MOR (C ) in the DRG of tumor-bearing mouse on days 14 and 28. Real-time reverse transcription polymerase chain reaction was carried out on messenger RNA (mRNA) obtained from thoracic 6–13 th and L1–3 DRG. The mRNA concentrations were normalized to those for glyceraldehyde-3-phosphate dehydrogenase (housekeeping gene), and the results are presented as the means ± SD. *P < 0.05 versus  control group, one-way ANOVA followed by the Bonferroni multiple comparisons test.

Fig. 4. Transcriptional regulation of substance P, calcitonin gene-related peptide (CGRP), and μ-opioid receptor (MOR) in the dorsal root ganglia (DRG) induced by peritoneal carcinomatosis. Expression of substance P (A ), CGRP (B ), and MOR (C ) in the DRG of tumor-bearing mouse on days 14 and 28. Real-time reverse transcription polymerase chain reaction was carried out on messenger RNA (mRNA) obtained from thoracic 6–13 th and L1–3 DRG. The mRNA concentrations were normalized to those for glyceraldehyde-3-phosphate dehydrogenase (housekeeping gene), and the results are presented as the means ± SD. *P < 0.05 versus  control group, one-way ANOVA followed by the Bonferroni multiple comparisons test.

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