Fig. 2. Right ventricle (RV) pressure-volume (PV) loops. Representative recordings of RV PV loops in a control (A , rat #41) and a monocrotaline-treated rat (B , rat #77) during 1.5 MAC concentration of the three different investigated inhalation agents. Solid lines  represent exponential fitting of end-systolic data points (end-systolic pressure volume-relationship [ESPVR]). Dotted lines  represent linear relationships between the first PV loop of end-systolic and end-diastolic data points resulting in a negative slope corresponding to baseline pulmonary arterial elastance (E^a). Note the overall increased ESPVR in monocrotaline treated rats as well as the increased E^aassociated to the leftward displacement of V⁰with desflurane inhalation. MAC = minimum alveolar concentration; RV ESP = right ventricle end-systolic pressure.