Fig. 8. Ceftazidime lung tissue concentrations in piglets with infected lungs according to aeration of lung segments. Pneumonia was caused by bronchial instillation of Pseudomonas aeruginosa with a decreased sensitivity to ceftazidime. Ceftazidime was administered by vibrating plate nebulizer at a dose of 25 mg/kg every 3 h or intravenously, using a continuous infusion of 90 mg·kg−1·day−1. Histological severity of pneumonia characterizing lung segments (n number) was classified as mild (bronchiolitis, small foci of pneumonia, interstitial pneumonia) or severe (confluent pneumonia, necrotizing pneumonia). The dashed lines indicate minimal inhibitory concentrations of inoculated P. aeruginosa . After ceftazidime nebulization, ceftazidime trough tissue concentrations were significantly lower in pulmonary segments with severe pneumonia. (Reprinted from Ref. 41with the permission of the publisher.)