Fig. 2. Delayed emergence in Dbh −/− mice is not due to a relative volatile anesthetic overdose. (A) Time to LORR in Dbh −/− and Dbh +/− mice when each group is exposed to their respective ED95 dose for eliciting LORR. (B) Time until RORR in Dbh −/− (black ) and Dbh +/− (colored ) mice after a 2-h exposure to each group’s respective volatile anesthetic ED95 (n = 12/group). There is a significant effect of genotype on emergence F1,66 = 12.33, P value less than 0.0003, but not upon induction F1,66 = 0.14, P = 0.7132. Bars show mean ± SEM. Dbh = dopamine β-hydroxylase; Halo = halothane; Iso = isoflurane; LORR = loss of righting reflex; RORR: return of righting reflex; Sevo = sevoflurane.