Fig. 3.
Coadministration of CX717 (intraperitonealy) with propofol (intraperitonealy) reduces respiratory depression induced by propofol in neonatal rats in vivo. A, Whole body plethysmographic measurements of the frequency and depth of breathing from an unrestrained newborn rat. Propofol (30mg/kg) induced depression of respiratory frequency that was not affected by the coadministration of the vehicle 2-hydroxypropyl-β-cyclodextin (HPCD). B, In another neonatal rat, coadministration of CX717 (20mg/kg) with propofol markedly attenuated the propofol-induced respiratory depression. C, Population data showing changes in respiratory parameters (relative to control): fR (frequency), VT (tidal volume), VE (minute ventilation) in response to propofol (30mg/kg) administration with the coadministration of vehicle or CX717 (20mg/kg). * P < 0.05; n = 5 each.