Fig. 5.
Administration of CX717 (20–25mg/kg, intravenously) prevented propofol-induced lethal apnea in adult rats. A, Whole body plethysmographic measurements of the frequency and depth of breathing from an adult rat. Administration of a high dose of propofol (30mg/kg) over a short period (~20 s) induced a profound, lethal respiratory depression. Vehicle 2-hydroxypropyl-β-cyclodextin (10% HPCD) injection with propofol (30mg/kg, indicated by arrow) administration had no significant effects on respiratory depression. B, Coadministration of CX717 (20mg/kg) with propofol (30mg/kg, indicated by arrow) reduced the severity of propofol-induced apnea and depression of respiratory frequency and prevented death.