Fig. 6.
Inflammatory mediators expressed in lung parenchyma at end of 4-h ventilation. (A) Levels of interleukin-1β (IL-1β) expression (pg/ml). Overall, IL-1β level was the highest in left lower dorsal lobe (LLD) and lowest in left middle ventral lobe (LMV), with statistical significance across all treatment groups. The higher frequency groups (high-frequency oscillatory ventilation [HFOV]-9 Hz group) exhibited markedly decreased IL-1β expression than the 3 Hz and conventional mechanical ventilation (CMV) groups across all three pulmonary areas, and in the total lung than 3 Hz and CMV. (B) Levels of IL-6 expression (pg/ml). The least amount of IL-6 expression was found in the HFOV-9 Hz group across all three pulmonary areas and in the total lung. * P < 0.05 and ** P < 0.01 versus LMV; ∆ P < 0.05 and ∆∆ P < 0.01 versus LLV. # P < 0.05 versus HFOV-3 Hz. § P < 0.05 and §§ P < 0.01 versus CMV. LLV = left low ventral lobe.