Fig. 5.
End-plate potentials (EPPs) during train-of-four (TOF) stimulation at normal levels of acetylcholine release in the absence of blocking drugs. Normal physiological saline solutions were used. (A) Shows raw data from an experiment in which the average number of quanta released was 21 as measured directly from the ratio of the mean EPP amplitude to the miniature EPP amplitudes. (B) Shows the average data from all four preparations. As described in the text, no differences were observed between the TOF ratio in the presence of the neuromuscular-blocking drugs such as tubocurarine or vecuronium (these experiments were made in physiological Ca2+current solution) and those made in the absence of blocking drugs in normal bathing solutions.
