Fig. 4.
Effects of different doses of ICI 174,864 with or without 1/2 and 1/4 volume of lactated Ringer’s solution (LR) on uncontrolled hemorrhagic shock in rats (n = 10 per each group). Data are mean ± SD. (A–C) Changes in mean arterial pressure (MAP) in ICI 174,864 with no infusion of LR, with 1/4 volume of LR infusion, and with 1/2 volume of LR infusion; (D-F) blood loss; (G and J) survival number and survival time in ICI 174,864 without infusion of LR; (H and K) survival number and survival time in ICI 174,864 with 1/4 volume of LR infusion; (I and L) survival number and survival time in ICI 174,864 with 1/2 volume of LR infusion. 0.1, 0.3, 0.5, 1, 3, 5 in the figure indicates 0.1, 0.3, 0.5, 1, 3, and 5 mg/kg of ICI 174,864; Ctl = control; ICI = ICI 174,864, delta-opioid receptor antagonist. *P < 0.05 as compared with or without infusion LR group.

Effects of different doses of ICI 174,864 with or without 1/2 and 1/4 volume of lactated Ringer’s solution (LR) on uncontrolled hemorrhagic shock in rats (n = 10 per each group). Data are mean ± SD. (A–C) Changes in mean arterial pressure (MAP) in ICI 174,864 with no infusion of LR, with 1/4 volume of LR infusion, and with 1/2 volume of LR infusion; (D-F) blood loss; (G and J) survival number and survival time in ICI 174,864 without infusion of LR; (H and K) survival number and survival time in ICI 174,864 with 1/4 volume of LR infusion; (I and L) survival number and survival time in ICI 174,864 with 1/2 volume of LR infusion. 0.1, 0.3, 0.5, 1, 3, 5 in the figure indicates 0.1, 0.3, 0.5, 1, 3, and 5 mg/kg of ICI 174,864; Ctl = control; ICI = ICI 174,864, delta-opioid receptor antagonist. *P < 0.05 as compared with or without infusion LR group.

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