Fig. 4.
(A–D) Effects of LR12 on blood leukocyte count. Animals that received placebo demonstrated a leukopenia (mean leukocytes count, 7.6 g/l vs. 21.1 g/l at H0) at 2 h after challenge (group effect: P < 0.001 vs. control and LR12 groups) resulting from neutropenia, lymphopenia, and monocytopenia. LR12 administration totally blunted neutropenia. A marked leukocytosis, mainly interesting neutrophils, occurred at the end of the 8-h study period (P < 0.001). Ctrl = control group; LPS = lipopolysaccharide.