Fig. 5.
LR12 administration reduced cytokine plasma concentrations. (A–G) Lipopolysaccharide (LPS) induced an increase of interleukin (IL)-6, IL-8, interferon (IFN)-γ, monocyte chimoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1α, MIP-1β, and tumor necrosis factor (TNF)-α peaking between H1 and H2. LR12 decreased IL-6, IL-8, MCP-1, MIP-1α, MIP-1β, and TNF-α plasma concentrations by 20 to 50%. Indicated P values are for LR12 versus control group effect.

LR12 administration reduced cytokine plasma concentrations. (A–G) Lipopolysaccharide (LPS) induced an increase of interleukin (IL)-6, IL-8, interferon (IFN)-γ, monocyte chimoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1α, MIP-1β, and tumor necrosis factor (TNF)-α peaking between H1 and H2. LR12 decreased IL-6, IL-8, MCP-1, MIP-1α, MIP-1β, and TNF-α plasma concentrations by 20 to 50%. Indicated P values are for LR12 versus control group effect.

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